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Genes Brain Behav.

Roadmap Epigenomics

Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life. Methylation alterations of WT1 and homeobox genes in inflamed muscle biopsy samples from patients with untreated juvenile dermatomyositis suggest self-renewal capacity. Arthritis Rheum. DNA methylation alterations in response to pesticide exposure in vitro. Environ Mol Mutagen.

Saving lives through blood-based cancer detection

Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro. Environ Toxicol Pharmacol. Genetic and epigenetic variations contributed by Alu retrotransposition. BTECH: a platform to integrate genomic, transcriptomic and epigenomic alterations in brain tumors. Genome-wide quantitative assessment of variation in DNA methylation patterns. Nucleic Acids Res.

Epigenomics and Computational Biology Laboratory

Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors. BMC Cancer. Epigenomic analysis of Alu repeats in human ependymomas.

Detecting Cancer in Blood

Global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2'-deoxycytidine results in increased tumorigenicity. SNP-based prediction of the human germ cell methylation landscape.

High-throughput sequence-based epigenomic analysis of Alu repeats in human cerebellum. A primer design algorithm for global analysis of CpG methylation. Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas.

Epigenomics and transcriptomics

Transcriptional profiling of stress response in cultured porcine islets. Biochem Biophys Res Commun.

1. Introduction

Recent patents on the identification and clinical application of microRNAs and target genes. Global assessment of promoter methylation in a murine model of cancer identifies ID4 as a putative novel tumor suppressor gene in human leukemia. Down-regulation of death associated protein kinase 1 DAPK1 in chronic lymphocytic leukemia. Cell , Driver mutations in histone H3. Cancer Cell , 22 4 : , Nat Med.

Tagmentation-based whole-genome bisulfite sequencing. Nat Protoc.

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Hypermutation of the inactive x chromosome is a frequent event in cancer. Cancer Cell , , Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer. Nat Rev Genet. The goal of the Roadmap Epigenomics project is to create a set of reference epigenomic maps for stem cells, differentiated cells, and primary tissues.

nightenriwonbe.ml The project is mapping DNA methylation sites, histone modification sites, transcription factor binding sites, and chromatin accessibility sites. Citation s Bernstein, BE et al. Nat Biotechnol.